Effects of Alloxan-Induced Diabetes Mellitus on Blood Metabolites and Serum Minerals and Hormones in Rabbits (Lepus cuniculus) in Relation to Starch Supplementation and Season
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چکیده
The objective of the present study was to evaluate the effects of starch supplementation and season (summer vs winter) on blood metabolites and certain minerals and hormones in alloxan-diabetic and normal nondiabetic rabbits. In both seasons,alloxan induced significant lowering of serum insulin level associated with significantly higher plasma glucose levels. Starch supplementation increased insulin and glucose levels significantly in both seasons. Diabetes significantly decreased serum albumin level during winter. Diabetic rabbits had significantly higher serum urea levels in both seasons; non-diabetic rabbits had significantly higher urea level during winter compared to summer values. Non-diabetic rabbits fed Lucerne only had significantly higher creatinine levels that were significantly higher in summer than winter in all experimental groups. In both seasons, diabetic rabbits had higher serum total lipids levels. Starch supplementation caused significant increase in triglyceride level in summer. Diabetic-starch supplemented rabbits had significantly higher serum cholesterol level compared to other groups. With lucerne feeding, diabetic rabbits had significantly higher cholesterol level compared to non-diabetic state. Cholesterol was significantly higher during summer than winter in diabetic starch supplemented rabbits and in non-diabetic rabbits. In both seasons, diabetic rabbits fed Lucerne maintained significantly higher serum Na level compared to other experimental groups; Na level was significantly higher in diabeticstarch supplemented and non-diabetic rabbits during winter compared to respective summer values. Non-diabetic starch supplemented rabbits had significantly higher serum K level in winter compared to summer values.Non-diabetic starch supplemented rabbits had higher cortisol level in summer compared to winter. Diabetic-starch supplemented rabbits had significantly higher cortisol level compared to other groups in winter. Cortisol level was significantly higher in winter compared to summer values in diabetic rabbits. The findings have relevance for understanding pathophysiological changes in human diabetes.
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